Our research is editorially independent but we
may earn a commission for purchases made through our links.
Considered a classic all-American road trip, a drive in the Florida Keys means exploring picture-perfect islands with coral reefs perfect for snorkeling, some of Florida’s top state and national parks and eating freshly-caught seafood at local restaurants. Starting in Key Largo, the most comprehensive Florida Keys road trip will take you to Tavernier, Islamorada, Long Key, Marathon, the Lower Keys and Key West. Along the way, make a pit stop and stay at one of these tropical-inspired Airbnbs and VRBO’s to enjoy perks such as beachfront access, outdoor pools and access to water-based adventures.
Ready to create your Florida Keys itinerary? Make sure to add outdoor activities in Key Largo, fishing excursions in Islamorada and paddling adventures in Marathon to your route. After you cross the famous Seven Mile Bridge and explore the Lower Keys, continue on U.S. 1 to Mile Marker 0 and embrace the anything-goes attitude and colorful attractions in Key West.